TNF and Insulin resistance: PCOS-specific editing events in abdominal adipose tissue were enriched in immune response tolerance induction and regulation of TNF secretion, and we also identified specific genes such as HLA-G and WNT5A. Previous studies have identified the relationship between serum HLA-G level and high-density lipoprotein cholesterol, insulin resistance, ovarian hyperandrogenism, and oxidative stress in women with PCOS (34).