Genes enriched in inflammation, such as lymphotoxin beta (LTB), TNF receptor-associated factor 6 (TRAF6), and nuclear factor kappa B subunit 1 (NFKB1), and genes enriched in stem cell population maintenance, such as delta-like canonical Notch ligand 1 (DLL1), notch receptor 1 (NOTCH1), NOTCH2, replication timing regulatory factor 1 (RIF1), FZD7, terminal uridylyl transferase 4 (TUT4), hook microtubule-tethering protein 3 (HOOK3), DNA ligase 4 (LIG4), forkhead box P1 (FOXP1), and forkhead box O1 (FOXO1), were merely edited in the subcutaneous adipose tissue of PCOS. The gene discussed is LIG4; the disease is polycystic ovary syndrome.