NR1I3 and liver disorder: The persistence of HDI-transfected transgene expression in liver for many weeks [59] suggests that HDI-STARR-seq will also be useful, not only for assaying global changes in enhancer activities in response to short-term drug or chemical exposure, as shown here using the CAR agonist ligand TCPOBOP, but also longer-term, during the course of liver disease development, e.g., following hepatotoxin exposure or when feeding high fat dietary regimens that induce steatohepatitis over a period of many weeks.