Other genes identified in our analysis that are linked with human syndromic brain phenotypes include: TUBB3 (pruning of misguided axons during development (30); FUS (Fronto-temporal lobe dementia (31); P4HTM (HIDEA syndrome(32); and MTMR10 (human 15q13.3 microdeletion syndrome (33). This evidence concerns the gene FUS and Down syndrome.