<i>Slc11a2</i> <sup>KD</sup> cells from <i>APP/PS1</i> females also exhibited decreased expression of markers associated with disease-associated microglia (DAMs), such as <i>Apoe</i>, <i>Ctsb, Csf1</i>, and <i>Hif1α</i>.<h4>Conclusions</h4>This work suggests a sex-specific role for microglial iron import gene <i>Slc11a2</i> in propagating behavioral and cognitive phenotypes in the <i>APP/PS1</i> model of AD. Here, HIF1A is linked to Alzheimer disease.