These studies determined the effects of microglial-specific knockdown of <i>Slc11a2</i> on AD-related cognitive decline and microglial transcriptional phenotype.<h4>Methods</h4><i>In vitro</i> experiments and RT-qPCR were used to assess a role for DMT1 in amyloid-β-associated inflammation. This evidence concerns the gene SLC11A2 and Mental deterioration.