Paired E169 tumours had a high number of shared SNVs (n=3158) including mutations in TERT and BCOR; however, the number of SNVs doubled in the post-CVD (n=12702) tumour including mutations in TP53, RPL5 and POLE (DNA Polymerase Epsilon) (Figure 8B). This evidence concerns the gene RPL5 and neoplasm.