We previously generated osteocyte NPY knockout (Dmp1‐iCre; Npyfl/fl) mice and reported the contributory role of osteocyte NPY in the development of osteoporosis.[13] To determine the role of osteocyte NPY in osteoarthritis, the Dmp1‐iCre; Npyfl/fl mice and their control mice (Npyfl/fl mice) were subjected to DMM surgery or sham operation. This evidence concerns the gene NPY and osteoporosis.