Subchondral bone offers mechanical support for articular cartilage and its abnormal remodeling contributes importantly to the onset and development of osteoarthritis.[19] Currently, it is still unclear whether osteocytes, the most abundant (90–95%) bone cells within the bone matrix[20] and one of the most abundant sources of NPY in the periphery,[12, 13] are involved in the pathogenesis of osteoarthritis and the protective effects of intermittent fasting against osteoarthritis through NPY. This evidence concerns the gene NPY and osteoarthritis.