NPY and osteoarthritis: In the brain, a tissue that abundantly expresses NPY, however, showed no significant change of NPY expression upon DMM surgery but exhibited a marked increase of NPY in DMM mice after intermittent fasting treatment (Figure S2A,B, Supporting Information), suggesting that brain NPY is not involved in the pathogenesis of DMM‐induced osteoarthritis and does not contribute to NPY accumulation in the osteoarthritic joint.