A recent study also showed that the infiltration of inflammatory macrophages was significantly increased in the heart of an ICIs‐associated myocarditis mouse model (Ctla‐4+/−Pdcd1−/− mice).[30] The question remained to be addressed whether the increased proportion of M1 Mφ subpopulation is attributable to anti‐CTLA4 m2a antibody‐mediated infiltration of Ccl5‐neutrophil subpopulation, albeit Ccl5‐neutrophil subpopulation‐mediated interferon gamma signaling and response to Tnf was significantly increased in the MZs. The gene discussed is CCL5; the disease is myocarditis.