CELSR1 and ischemic cardiomyopathy: As stated in previous studies, PCDH1 (Protocadherin 1) mediated cell–cell adhesion through homotypic interactions [20], CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1) regulated endothelial adherens junctions and directed cell rearrangements during valve morphogenesis [21], and PCDHGA3 worked as one of the cell adhesion molecules in human ischemic cardiomyopathy [22].