The anti-tumor effect of CD276 Dash CAR-T at the high doses (1E7 CAR-T cells) was similar to that of conventional CAR-T, but the mice died at about 40 days after CAR-T injection due to the rapid and massive expansion of CD276 Dash CAR-T in vivo (Fig. 4b–d). This evidence concerns the gene CD276 and neoplasm.