The term HGBCL, NOS is used for histologically high-grade B-cell lymphomas without specific underlying genetic abnormalities that would mandate classification as another entity, such as concurrent rearrangements of BCL2 and MYC.(2) WHO-HAEM5 emphasizes the importance of the presence or absence of Epstein-Barr virus (EBV) in cases of Burkitt lymphoma which may correlate more precisely with pathogenesis and genetic features than the traditional epidemiological division into endemic, sporadic and immunodeficiency-associated Burkitt lymphoma.(62). This evidence concerns the gene MYC and B-cell non-Hodgkin lymphoma.