MDK and neoplasm: Herein we revealed the modulatory effect of VIS on the gene connected with ‘positive regulation of vasculogenesis’ (GO:2001214), CD34, as well as on the expression of several genes connected with angiogenesis, like the endosialin gene (CD248), KLF2, MDK, and ANG. VIS caused an increase in the expression of the CD248 gene which was reported as a potentially important marker of embryonic and tumour vascularization.