Our findings indicated positive correlations between AGTR1 (R = 0.27, p = 0.021) and XPA (R = 0.24, p = 0.041) and PDSS scores, while CALR (R=-0.25, p = 0.033) and RBM14 (R=-0.23, p = 0.046) exhibited negative correlations with PDSS scores, suggesting their potential role in circadian rhythm disturbance among PD patients (Fig. 10G-J). The gene discussed is CALR; the disease is Parkinson disease.