IL6 and acute kidney injury: Furthermore, the presence of AKI at D5-D7 was associated with the initial pro and anti-inflammatory response as both IL-6 and IL-10 levels measured at D1-2 were independently associated with AKI at D5-7 (OR 1.12 [1.03–1.22], p = 0.009 and OR 1.25 [1.07–1.47], p = 0.004 respectively) after adjusting for age, modified SOFA score at D1-2 and presence of AKI at D1-2.