A significant indicator of muscle atrophy is the overactivation of the ubiquitin–proteasome degradation system, highlighted by the upregulation of E3 ubiquitin ligases such as muscle atrophy F-box (MAFbx, also known as Atrogin-1), Muscle RING Finger-1(MuRF1, also known as Trim63), and TNF receptor associated factor 6 (Traf6) [10–12], which can be triggered by factors such as proinflammatory cytokines, oxidative stress, and fluctuations in energy levels that then stimulate the ubiquitin–proteasome proteolytic system through various downstream signaling cascades. Here, FBXO32 is linked to muscle atrophy.