TRIM63 and muscle atrophy: A significant indicator of muscle atrophy is the overactivation of the ubiquitin–proteasome degradation system, highlighted by the upregulation of E3 ubiquitin ligases such as muscle atrophy F-box (MAFbx, also known as Atrogin-1), Muscle RING Finger-1(MuRF1, also known as Trim63), and TNF receptor associated factor 6 (Traf6) [10–12], which can be triggered by factors such as proinflammatory cytokines, oxidative stress, and fluctuations in energy levels that then stimulate the ubiquitin–proteasome proteolytic system through various downstream signaling cascades.