The cutoff value of 18 ng/mL of serum MMP-7 levels classified 395 patients as BA and 292 as non-BA cases in the prospective cohort, resulting in a diagnostic sensitivity of 95.9% (379/395; 95% CI: 93.5–97.7%), a specificity of 87.3% (255/292; 95% CI: 83.0–90.9%), a PPV of 91.1% (379/416; 95% CI: 87.9–93.7%), and a NPV of 94.1% (255/271; 95% CI: 90.6–96.6%), respectively (Fig. 3C). This evidence concerns the gene MMP7 and breast angiosarcoma.