On the opposite side, criteria B11 (ACE inhibitors or AR blockers in patients with hyperkalemia), B8 (thiazide diuretics with current significant hypokalemia, hyponatremia, hypercalcemia or gout history) and A1 restricted to hypolipidemic drugs reached more than 90% of reduction (Table 2). The gene discussed is ACE; the disease is Hyponatremia.