From this list, four criteria reached a percentage above 10%: E5 (vitamin D supplement in older people who are housebound or experiencing falls with osteopenia), 22.4%; H2 (laxative in patients receiving opioids regularly), 13.0%; A8 (appropriate beta-blocker with stable systolic heart failure), 11.2%; and A6 (ACE inhibitors with systolic heart failure and/or documented coronary artery disease), 10.6%. This evidence concerns the gene ACE and systolic heart failure.