On the other hand, secondary adrenal insufficiency is commonly associated with pituitary inflammation, which affects adrenal hormone secretion through the pituitary-adrenal axis and manifests as a synchronous decrease in morning cortisol and ACTH levels.The consequences of pituitary gland damage caused by immunotherapy, adrenal hormone and thyroid hormone disorders are more serious and the incidence is not uncommon, so we routinely test cortisol and ACTH in non-small cell lung cancer patients before the chemotherapy and immunotherapy in each treatment cycle. The gene discussed is POMC; the disease is Adrenal insufficiency.