CIB1 and alveolar rhabdomyosarcoma: Moreover, in the most aggressive ARMS subtype, we highlighted the modulation of specific cell cycle inhibitors, as the INK family member p16, p21 and p27 Cip/Kip proteins, in agreement with Bergantin et al. who reported p21 up-regulation at mRNA and protein levels only in ARMS models treated with 10 μM SFN for 12 h [31].