Platelet depletion did not significantly affect systemic IL-1β, TNFα, and IL-6 levels in mice (Appendix Fig. S3A), consistent with previous findings in LPS challenge and bacterial infection (Carestia et al, 2019; Claushuis et al, 2016; de Stoppelaar et al, 2014; Xiang et al, 2013). The gene discussed is IL1B; the disease is bacterial infectious disease.