Together, our data demonstrate the existence of a novel WT1 isoform (P-tWT1) in humans, which closely resembles the murine E6-tWt1 in mRNA structure but possesses a productive in-frame start codon within the additional intronic sequence similar to E7-tWt1, and that expression of this WT1 isoform correlates with a negative long-term outcome for ovarian cancer patients. Here, WT1 is linked to ovarian carcinoma.