In our previous research, we developed an STZ-induced effective and clinically relevant AD-like model in non-human primates and rodents through intra-cisternal magna (ICM) route, characterized by cerebral and hippocampal damage, disintegration of the neurovascular unit, Aβ deposition, neuroinflammation, and Cdk5 activation57–60. The gene discussed is CDK5; the disease is Alzheimer disease.