Furthermore, to validate the effect of Prx1 on the molecular signal pathway in the progression of STZ-induced AD-like pathologies (neuronal apoptosis, synaptic function, tau pathology, and mitochondrial fragmentation), we determined the change in calpain, cdk5, and mitochondria morphology using antioxidant molecule and Ca2+ chelator. This evidence concerns the gene CDK5 and Alzheimer disease.