Signs of CAD activity can even be detected in cancer cells growing in the absence of an apoptotic stimulus (Haimovici et al, 2022; Liu et al, 2017); in tumor cell lines in vitro, spontaneous CAD activity is the result of spontaneous, non-lethal activation of the mitochondrial apoptosis apparatus (Haimovici et al, 2022). Here, CAD is linked to cancer.