LEP and obesity due to melanocortin 4 receptor deficiency: To investigate the effects of primary mechanisms of obesity-induced cancer on HCC risk, we initially included a total of 263 SNPs as IVs associated with C-reactive protein levels, 6 SNPs with circulating leptin levels, 14 SNPs with adiponectin, 9 SNPs with severe insulin-resistant type 2 diabetes (Table S6).