Upon conducting the Q test analysis, heterogeneity was evident among the associations involving waist-to-hip ratio, C-reactive protein levels, circulating leptin levels, and HCC, as well as BMI and C-reactive protein levels, body fat percentage and severe insulin-resistant type 2 diabetes, and adiponectin, C-reactive protein levels, circulating leptin levels (P < 0.05). This evidence concerns the gene ADIPOQ and hepatocellular carcinoma.