Spearman correlation analyses were employed to elucidate the interplay between SLC3A2, RPN1, NCKAP1, and SLC7A11 within the glioma landscape (Fig. 1D-F), revealing the strongest correlation between SLC3A2 and SLC7A11 (R = 0.242, P < 0.001). This evidence concerns the gene RPN1 and central nervous system cancer.