Reportedly, acetaldehyde can produce angiogenesis and telangiectasia through the expression of vascular endothelial growth factor (VEGF), as experimentally demonstrated in the chick embryo chorioallantoic membrane model28, and nicotine provokes dry flushing via vasodilation action of prostaglandins on vascular smooth muscle29. The gene discussed is VEGFA; the disease is Telangiectasia.