CXCR4 and neoplasm: The levels of chemokine receptors and chemokines (CXCR3, CCR6, CXCR4, CCL5, CXCL6 and CXCL12) were higher in the C0 vs. C4 group, which enabled anti-tumor cells migrate to tumor lesions (Fig. 2A, Supplementary Fig. 4)13.