C4B and metastatic malignant neoplasm: S7d). It was found to have 22 deleterious mutations out of 79 missense mutations affecting CH and spectrin repeat domain (Fig. 3d). The spectrin-based domain protects epithelial cells from mechanical stress and is involved in the homeostasis of water and salt. The mutation in the spectrin domain may lead to its loss of function which results in defective TGF-B signaling and cell cycle deregulation. The loss of this domain is a marker of metastatic cancer cells 43.