In the evidence chain analysis, Alzheimer’s disease is linked to it through the inflammatory cytokine, IL6. Commonly seen in various neurodegenerative diseases, neuroinflammation and inflammatory cytokines are important drivers of pathophysiology, and there is strong evidence that inflammatory cytokines, such as IL6 are involved in Parkinson’s disease and Alzheimer’s disease progression98,99. Here, IL6 is linked to early-onset autosomal dominant Alzheimer disease.