As conformation of this, Sulindac was found to normalize behaviour and improve cognition in a mouse model of FXS and significantly reduce the expression of both PTGS1 (P = 0.0269) and PTGS2 (P = 0.0042) in the cortex of Fmr1 KO1 mice (Table 2). This evidence concerns the gene PTGS2 and fragile X syndrome.