In fact, the results obtained provided a qualitative, yet with quantitative characteristics, agreement with reported clinical phenotype of CAH patients: Patients with mild CAH have been often reported to be asymptomatic (cortisol concentrations following similar trajectories throughout the day) or with signs of androgen excess (increased ACTH, around 10-fold higher morning peak), while for patients with severe CAH excess androgen production was even more pronounced (increased ACTH, around 100-fold higher morning peak) [4, 6, 31, 32]. The gene discussed is POMC; the disease is congenital adrenal hyperplasia.