Intracerebroventricular injection of soluble Fn14-Fc decoy receptor or anti-TNFSF12 antibody immediately after mouse cerebral infarction significantly reduced ischemic cerebral infarction volume and microglia activation and extent of apoptotic cell death in animal experiments [58], and the decoy receptor CD163 may block TNFSF12/Fn14 from acting and thus protect against CES. This evidence concerns the gene TNFSF12 and cerebral infarction.