TNFSF12 and atrial fibrillation: Although none of the SNPs were included when TNFSF12 or AF was analyzed in two-sample MR, complementary analysis with SMR revealed that TNFSF12 was protective against AF (beta =  − 0.16; P = 9.80 × 10−8), and colocalization analysis also yielded a positive result (H3 + H4 = 0.99).