In the multivariate logistic regression model, LETM and AQP4-IgG seropositivity were independent predictors for the development of spinal movement disorders (P = 0.022, RR 6.416, 95% CI [1.308–31.474]; P = 0.022, RR 43.670, 95% CI [1.723–1107.0], respectively), while MOG-IgG and African American race were associated with a lower risk of developing these movement disorders (P = 0.022, RR 0.023, 95% CI [0.001–0.580]; P = 0.045, RR 0.151, 95% CI [0.024–0.961], respectively). Here, AQP4 is linked to movement disorder.