This and the finding that two stereotyped BCR CLL groups sharing VH-CDR3 homology with OAMZL12 and OAMZL26 both were also reactive with U1-/U-snRNP complex proteins strongly suggests that this particular form of autoreactivity may be more common and occur in a variety of B-cell malignancies. The gene discussed is LSM2; the disease is B-cell chronic lymphocytic leukemia.