UBD and lung adenocarcinoma: In our previous study, we have shown that FAT10 down-regulates IFNβ secretion upon influenza A virus (IAV) infection in lung adenocarcinoma (A549) cells because A549 cells stably expressing FLAG-FAT10 secreted less IFNβ as compared with A549 WT cells infected with IAV (Saxena et al, 2024).