assessed the expression and prognostic significance of peripheral blood miR-448 and its target gene SIRT1 in patients with obesity and T2DM undergoing laparoscopic bariatric surgery, revealing that miR-448 expression decreased while SIRT1 mRNA and protein expression increased, particularly in the effective treatment group [109]. This evidence concerns the gene SIRT1 and obesity due to melanocortin 4 receptor deficiency.