To further characterize the GLI2‐expressing epithelial cells in leukoplakia, we re‐analyzed the gene profiles of epithelial cells based on GLI2 expression and identified 5491 upregulated and 1153 downregulated genes in GLI2‐expressing cells compared to cells without GLI2 expression (p <  0.05, Figure 5E and Table S4, Supporting Information). Here, GLI2 is linked to leukoplakia.