The number of nuclei per cluster, as summarized in Table S3, Supporting Information, showed a significant accumulation of ACTA2‐, COL1A1‐, LOXL1‐, and TGFB1‐expressing fibroblasts in leukoplakia tissue, in contrast to normal tissue (Figure 5C and Table S3, Supporting Information). This evidence concerns the gene COL1A1 and leukoplakia.