When visualizing the expression of several EMT‐related genes known to be upregulated in cancer and GLI2‐expressing cells from our snRNA‐seq dataset in a UMAP, we observed significant upregulation of genes such as AXIN2, FGFR2, HMGA2, NOTCH1, ROCK1, SMAD2, TGFB1, and TGFBR1 in the epithelial cells of leukoplakia tissue compared to normal tissue (Figure S17, Supporting Information). This evidence concerns the gene ROCK1 and Oral leukoplakia.