The number of nuclei per cluster, as summarized in Table S3, Supporting Information, showed a significant accumulation of ACTA2‐, COL1A1‐, LOXL1‐, and TGFB1‐expressing fibroblasts in leukoplakia tissue, in contrast to normal tissue (Figure 5C and Table S3, Supporting Information). The gene discussed is COL1A1; the disease is Oral leukoplakia.