Secondly, since RESV injection is known to inhibit oxidative neurotoxicity and apoptosis by modifying ROS-sensitive TRP channels in the DRGs of laboratory animals [25–27], we examined the protective effects of RESV through the attenuation of TRPV4 on the oxidative injury and programmed cell death (apoptosis) caused by diabetes mellitus. The gene discussed is TRPV4; the disease is diabetes mellitus.