The results showed a significantly better prognosis in the low-risk group than in the high-risk group in the subgroups of age > / ≤ 50 years, female, male, AFP > / ≤ 300 ng/ml, ALT > / ≤ 50 U/L, tumor size > / ≤ 5 cm, cirrhosis and BCLC stage A (P < 0.0001, P = 0.0017, P = 0.04, P < 0.0001, P = 0.01, P < 0.0001, P = 0.00098, P < 0.0001, P = 0.00023, P = 0.00086, P < 0.0001 and P < 0.0001, respectively) (Fig. 4e–p). This evidence concerns the gene AFP and neoplasm.