As a preliminarily investigation of whether PPP2R2B can affect the sensitivity of BC cells to cisplatin, CCK-8 assays were used to determine cisplatin IC50 values, and revealed that PPP2R2B knockdown increased the IC50 value of cisplatin in BC cells, whereas IC50 values were decreased by PPP2R2B overexpression (Fig. 2C, D, Fig. S3E, F). The gene discussed is PPP2R2B; the disease is breast cancer.