It has been reported that FERMT1 and EMT play a regulatory role in cancer, for example, FERMT1 inhibits the migration, invasion and EMT of oral squamous cell carcinoma cells by inhibiting the PI3K/AKT signaling pathway, which becomes a new target for the anti-metastasis of cancer (Wang and Chen 2021). The gene discussed is AKT1; the disease is oral cavity squamous cell carcinoma.