Firstly, analysis in HCC patients suggested that CD14+HLA-DR- M-MDSCs (p = 0.0399) was significantly higher in the group with low levels of apoE than in the high level apoE group; the abundance of CD11b+CD33+CD14-HLA-DR- e-MDSCs was significantly higher in the low level apoE group than in the normal level apoE group (p = 0.0327) and the high level apoE group (p = 0.0156). The gene discussed is CD33; the disease is hepatocellular carcinoma.