Lastly, our findings suggestthat caffeine may modulate multiple physiological functions of CaSR,including Ca2+ regulation, bone development, osteoporosis,cardiac rhythm, asthma, lactation, and cancer metastasis.1 Therefore, our finding warrants additional investigationof CaSR and caffeine to understand caffeine’s impacts on thehuman body. The gene discussed is CASR; the disease is asthma.