The MOG-IgG is the gold standard for diagnosing MOG-AD as it is 99% specific and 100% sensitive for MOG-AD [11,12]. With that being said, it is important to distinguish MOG-AD from the similarly presenting diseases of multiple sclerosis and AQP4 NMOSD as there are differences in treatment protocol and responses. Here, AQP4 is linked to Alzheimer disease.