While the pathological aggregation of plagues (amyloid) and tangles (tau proteins) is associated with AD, Lewy body proliferation with dementia with Lewy bodies (alpha-synuclein) (DLB), vascular damage with vascular dementia (VD), and neuroinflammation emerging as an important co-contributing pathway [33], all-cause reduction in overall neuronal function and a decreased capacity to maintain autonomic system complexity. The gene discussed is MAPT; the disease is Lewy body dementia.