IFNG and tuberculosis: Supplementary Figures 4, 5 show T cells enriched for CD62L, CD44, CD127 and CCR7 in the organs of vaccinated mice. Further, Supplementary Figure 6 illustrates that the DKO vaccinated but non challenged mice showed a stronger IFN-γ+ CD4 and CD8 T cells compared to BCG vaccine. We conclude that the Mtb-derived DKO vaccine generates a qualitatively superior T cell response against TB in mice compared to the BCG vaccine.