Strikingly, NKp46-depleted autoreactive splenocytes lost the ability to protect Rnlsmut cells from autoimmunity in both immunodeficient recipients, NOD-Prkdcscid (NOD.scid) mice and NOD.scid gamma (NSG) mice completely deficient for functional T, B, and NK cells (Figure 1C). This evidence concerns the gene NCR1 and Autoimmunity.