These alterations included SNVs in the genes CREBBP, LZTR1, IRF4, and fusions with FLI1. CREBBP encodes an acetyltransferase and is one of the most mutated genes in small cell lung cancer (48), however, co-mutations in this gene and NOTCH1 might negatively affect the benefit of adjuvant therapy in EGFR-mutated NSCLC tumors (49). This evidence concerns the gene NOTCH1 and non-small cell lung carcinoma.