Despite the significant increase in life expectancy for PLWHA worldwide due to antiretroviral therapy (ART), higher rates of AIDS-related or non-AIDS related diseases and death were found in patients with CD4+T cell counts below 200 cells/μl due to various factors such as reduced thymic output, dysfunction in bone marrow hematopoiesis, ongoing viral replication, immune exhaustion, and abnormal immune activation (Kelley et al., 2009; Li et al., 2011). The gene discussed is CD4; the disease is AIDS.