SF3B1 and acute myeloid leukemia: Other conditions with SF3B1 K700E include acute myeloid leukemia (AML), occurring in 2–5% of AML cases, chronic lymphocytic leukemia (CLL) observed in 15 % with poor prognosis, uveal melanoma in 15 %, pancreatic ductal adenocarcinoma (PDAC) in 4 % where K700E is an oncogenic driver, and 16 % in papillary breast cancers [9,[29], [30], [31]].