NFKB1 and colorectal carcinoma: The interest in IKKα out of canonical and non-canonical signalling has been investigated by Cook et al. Their recent work illustrated that in HCT116 CRC cells, IKKα, rather than IKKβ, was the dominant kinase for facilitating NFκB activity in response to inflammatory cytokines TNFα and IL-1, not IKKβ.