HIBCH and Tetralogy of Fallot: The first case of HIBCH deficiency was reported in 1982 by Brown et al. in a male infant with multiple physical malformations: dysmorphic facial features, multiple vertebral anomalies, tetralogy of Fallot, and agenesis of the cingulate gyrus, and corpus callosum, failure to thrive, and marked hypotonia [6] and was born to parents who were cousins.